{"id":70910,"date":"2024-12-31T13:37:44","date_gmt":"2024-12-31T13:37:44","guid":{"rendered":"https:\/\/efimarkets.com\/blog\/?p=70910"},"modified":"2024-12-31T13:43:47","modified_gmt":"2024-12-31T13:43:47","slug":"sangamo-stock-drops-50-after-pfizer-ends-gene-therapy-deal","status":"publish","type":"post","link":"https:\/\/bhimmarkets.com\/blog\/sangamo-stock-drops-50-after-pfizer-ends-gene-therapy-deal\/","title":{"rendered":"Sangamo Stock Drops 50% After Pfizer Ends Gene Therapy Deal"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"70910\" class=\"elementor elementor-70910\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37a7bee e-con-boxed e-flex e-con\" data-id=\"37a7bee\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d386a93 elementor-widget elementor-widget-image\" data-id=\"d386a93\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.13.0 - 24-04-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.investing.com\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" loading=\"lazy\" width=\"856\" height=\"400\" src=\"https:\/\/bhimmarkets.com\/blog\/wp-content\/uploads\/2024\/12\/1734943422138Astellas-Signs-License-Agreement-with-Sangamo-Therapeutics-to-Deliver-Genomic-Medicines.jpg\" class=\"attachment-large size-large wp-image-70918\" alt=\"Sangamo stock drops\" srcset=\"https:\/\/bhimmarkets.com\/blog\/wp-content\/uploads\/2024\/12\/1734943422138Astellas-Signs-License-Agreement-with-Sangamo-Therapeutics-to-Deliver-Genomic-Medicines.jpg 856w, https:\/\/bhimmarkets.com\/blog\/wp-content\/uploads\/2024\/12\/1734943422138Astellas-Signs-License-Agreement-with-Sangamo-Therapeutics-to-Deliver-Genomic-Medicines-300x140.jpg 300w, https:\/\/bhimmarkets.com\/blog\/wp-content\/uploads\/2024\/12\/1734943422138Astellas-Signs-License-Agreement-with-Sangamo-Therapeutics-to-Deliver-Genomic-Medicines-768x359.jpg 768w\" sizes=\"(max-width: 856px) 100vw, 856px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e70e37a e-con-boxed e-flex e-con\" data-id=\"e70e37a\" data-element_type=\"container\" data-settings=\"{&quot;content_width&quot;:&quot;boxed&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2815794 elementor-widget elementor-widget-text-editor\" data-id=\"2815794\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.13.0 - 24-04-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p data-pm-slice=\"1 1 []\"><span style=\"color: #000000;\">Sangamo stock drops 50% drop in shares during premarket trading on Tuesday following Pfizer\u2019s (NYSE: PFE) announcement to terminate their partnership on developing a gene therapy for hemophilia A (HemoA).<\/span><\/p><div><hr \/><\/div><h3><span style=\"color: #000000;\">Sangamo stock drops<\/span><\/h3><p><span style=\"color: #000000;\">With Pfizer\u2019s withdrawal, Sangamo has regained full rights to the HemoA therapy. The company has pledged to explore options for advancing the program, including potential new collaboration opportunities.<\/span><\/p><p><span style=\"color: #000000;\">However, this decision pushes back Sangamo\u2019s market entry timeline. Pfizer had initially planned to submit data for regulatory approval by early 2025, a goal now delayed.<\/span><\/p><div><hr \/><\/div><h3><span style=\"color: #000000;\">Why Pfizer Walked Away<\/span><\/h3><p><span style=\"color: #000000;\">Pfizer\u2019s decision follows a detailed evaluation of clinical trial data and feedback from experts. The company cited slow patient adoption of hemophilia A gene therapies, particularly among those with moderate to severe conditions. Pfizer emphasized the need to prioritize treatments with greater commercial and patient impact.<\/span><\/p><p><span style=\"color: #000000;\">Earlier trial results from Pfizer indicated that the therapy reduced annual bleeding episodes for patients. Despite this, the limited demand for gene therapies in this market influenced Pfizer\u2019s decision.<\/span><\/p><div><hr \/><\/div><h3><span style=\"color: #000000;\">Transition Plan and Future Outlook<\/span><\/h3><p><span style=\"color: #000000;\">The collaboration agreement between Sangamo and Pfizer will officially conclude on April 21, 2025. Until then, ongoing clinical trial participants will continue to receive monitoring as planned.<\/span><\/p><p><span style=\"color: #000000;\">Hemophilia A affects around 25 out of every 100,000 male births globally. The condition, caused by a genetic defect, hampers clotting factor production, leading to excessive bleeding during injuries or surgeries.<\/span><\/p><div><hr \/><\/div><h3><span style=\"color: #000000;\">Sangamo Focuses on Fabry Disease<\/span><\/h3><p><span style=\"color: #000000;\">Sangamo remains committed to advancing its therapy for Fabry disease. The company aims to submit this therapy, known as ST-920, for regulatory approval in late 2025. Analysts from Barclays (LON: BARC) highlighted the potential for significant upside through near-term licensing deals for this program.<\/span><\/p><div><hr \/><\/div><h3><span style=\"color: #000000;\">Market Reactions and Analyst Opinions<\/span><\/h3><p><span style=\"color: #000000;\">Analysts offered mixed reactions to Pfizer\u2019s decision:<\/span><\/p><ul data-spread=\"true\"><li><p><span style=\"color: #000000;\"><strong>Barclays<\/strong> reaffirmed its Overweight rating on Sangamo, describing the stock\u2019s sell-off as \u201coverdone\u201d due to the limited valuation assigned to the HemoA program.<\/span><\/p><\/li><li><p><span style=\"color: #000000;\"><strong>TD Cowen<\/strong> analysts expressed disappointment, attributing Pfizer\u2019s decision to the commercial challenges faced by Biomarin\u2019s Roctavian, another HemoA gene therapy. Roctavian\u2019s launch reportedly indicated a minimal market for therapies with 5-10 years of efficacy.<\/span><\/p><\/li><\/ul><div><hr \/><\/div><h3><span style=\"color: #000000;\">Conclusion<\/span><\/h3><p><span style=\"color: #000000;\">While Pfizer\u2019s exit presents significant challenges for Sangamo\u2019s HemoA program, the company\u2019s focus on advancing other treatments like its Fabry disease therapy provides hope for recovery. Investors remain cautious, but analysts see opportunities for upside in Sangamo\u2019s broader pipeline.<\/span><\/p><h5><span style=\"color: #000000;\">Trade Anytime, Anywhere with EFI\u00a0Markets<\/span><\/h5><p><span style=\"color: #000000;\">EFI Markets is a trusted<\/span>\u00a0<a href=\"https:\/\/efimarkets.com\/stocks\">stock market trading platform<\/a><span style=\"color: #000000;\">, making trading easy with its efficient interface and a variety of tools and features.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Sangamo stock drops 50% drop in shares during premarket trading on Tuesday following Pfizer\u2019s (NYSE: PFE) announcement to terminate their partnership on developing a gene therapy for hemophilia A (HemoA). Sangamo stock drops With Pfizer\u2019s withdrawal, Sangamo has regained full rights to the HemoA therapy. The company has pledged to explore options for advancing the &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/bhimmarkets.com\/blog\/sangamo-stock-drops-50-after-pfizer-ends-gene-therapy-deal\/\"> <span class=\"screen-reader-text\">Sangamo Stock Drops 50% After Pfizer Ends Gene Therapy Deal<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"categories":[12,3],"tags":[15,20,14,5,34,43],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Sangamo Stock Drops 50% After Pfizer Ends Gene Therapy Deal<\/title>\n<meta name=\"description\" content=\"Sangamo stock drops 50% as 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